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| Clinical observation on effect of Tangshenkang capsule on serumendothelin in patients with diabetic nephropathy in early stage |
| Hits 1810 Download times 1485 Received:March 20, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2014.08.07 |
| Key Words
Tangshenkang capsule;early diabetic nephropathy;serum endothelin-1 |
| Author Name | Affiliation | E-mail | | ZHOU Wen-jun | Department of Nephrology, The Affiliated Hospital of Tianjin Institute of Traditional Chinese Medicine, Tianjin 300120, China | | | SUN Lan-yun | Department of Nephrology, The Affiliated Hospital of Tianjin Institute of Traditional Chinese Medicine, Tianjin 300120, China | gao-xm@163.com |
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| Abstract
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| [Objective] To observe the effect of Tangshenkang capsule on serum Endothelin in patients with diabetic nephropathy (DN) and explore its mechanism. [Methods] The 60 patients with diabetic nephropathy in period of micro-proteinuria were selected. They were randomly divided into treatment group and control group with 30 cases in each group. Basic therapy was applied in both groups. In the treatment group the patients were also received Tangshenkang capsules simultaneously, 3 tablets, three times a day. A therapy course was two months. Three courses later, the excreting ratio of serum ET-1 and micro-albuminuria (UAER), the changes of glycated hemoglobin (Hbalc), cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) were observed before and after treatment. The statistical analysis was performed. [Results] Compared with control group the changes of serum ET-1 and urinary albumin, cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) had significant changes in the treatment group after treatment. [Conclusion] Tangshenkang capsule can reduce the concentration of serum ET-1, decrease microalbuminuria pos-sibly through improving hypercoagulability, reducing ischemia and anoxia and thus protecting the endothelial cells and alleviating the glomerular sclerosis |
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