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| The protective effect of astragalus polysaccharides on myocardial ischemia reperfusion injury |
| Hits 2010 Download times 1867 Received:March 27, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2014.08.15 |
| Key Words
astragalus polysaccharides;myocardial ischemia reperfusion injury;NF-κB |
| Author Name | Affiliation | | LI Tie-cheng | The Third Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, China | | ZHANG Jing-feng | The Third Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, China | | MA Bao-feng | The Third Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, China | | XU Fang | The Third Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, China | | LI De-sheng | The Third Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, China | | AI hao | The Third Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, China |
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| Abstract
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| [Objective] The aim of the present study was to investigate the protective effect of astragalus polysaccharides APS on myocardial ischemia reperfusion injury and the underlying mechanism. [Methods] The 48 SD rats were randomly divided into 4 groups: sham operation group (Sham group), myocardial ischemia-reperfusion (MI/R) group, APS (300 mg/kg) group and APS(600 mg/kg) group. Ischemia was produced by ligating the left anterior descending coronary artery. Myocardial infarct size was determined; myocardial pathological changes were observed, TNF-α, L-6, p65 and IκB protein expression was determined. [Results] Pretreatment of APS before MI/R could attenuate the morphological change of myocardial tissue, decreased the infracted sized, the content of TNF-αand IL-6, p65 protein content, and increased the IκB protein expression. [Conclusion] Astragalus polysaccharides pretreatment could attenuate MI/R injury through inhibition of the NF-κB signaling pathway, which lead to reduced inflammatory reaction. |
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