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| Study on the effect of acupuncturing Renzhong on proliferation of neural stemcells in central nervous systemofMCAOrat |
| Hits 1772 Download times 1437 Received:March 18, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2014.09.12 |
| Key Words
Renzhong;MCAO;NSCs;BrdU;nestin |
| Author Name | Affiliation | E-mail | | LUO Ding | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | FAN Xiao-nong | The Acupuncture and Moxibustion Institute of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Three-level Laboratory of dose-effect relationship of the State Administration of TCM, Tianjin 300193, China
Tianjin Acupuncture Key Laboratory of the State Administration of TCM, Tianjin 300193, China | fanxiaonong@163.com | | ZHAO Hai-ying | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | QI Zhao-shuang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | SHI Xue-min | The Acupuncture and Moxibustion Institute of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Acupuncture Encephalopathy Key Research Laboratory of the State Administration of TCM, Tianjin 300193, China | |
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| Abstract
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| [Objective] To discuss the mechanism of treating ischemic stroke by acupuncturing Renzhong. [Methods] We observed the population of BrdU+/nestin+ cells and expression of nestin protein in cortex, hippocampal and striatum in MCAO rat by double-labeling immunofluorescence and Western blot. [Results] Renzhong group's population of BdrU+, nestin+ and BrdU+/nestin+ cells were significant higher than that in normal group, sham group and control group in brain of MCAO rat(P<0.05). Renzhong group also had the highest ex-pression of nestin protein in cortex and hippocampal(P<0.05). [Conclusion] Acupuncture of Renzhong can enhance the proliferation of NSCs in central nervous system of MCAO rat. |
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