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| Effects of Tongmai Yangxin pill on myocardial hypertrophy caused by isopropylarterenol |
| Hits 1867 Download times 1388 Received:March 28, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2014.09.13 |
| Key Words
Tongmai Yangxin pill;isopropylarterenol;myocardial hypertrophy;anti-oxidation |
| Author Name | Affiliation | E-mail | | XU Wen-ping | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Lai-lai | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Yan-yan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MENG Xiao-wei | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Yi | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | vip_wangyi@126.com |
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| Abstract
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| [Objective] To explore the effects of Tongmai Yangxin pills on myocardial hypertrophy caused by isopropylarterenol(ISO) in rats. [Methods] The myocardial hypertrophy was reproduced by hypodermic injection of ISO, 5 mg/(kg·d)for 7 days at back skin in rats. Tongmai Yangxin pills 2.0, 1.0, 0.5 g/(kg·d) were administrated by gavaging from the second day for total 4 weeks. After the last ad-ministration, echocardiography was performed to detect the changes in cardiac structure and function in rats, calculate the quality and the indexes of whole heart and left ventricle, detect the superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity, malondi-aldehyde(MDA) and lipid peroxide (LPO) concentration in serum. [Results] In the model group the values of septal thickness (IVID) and left ventricular internal diameter (IVS) were increased in varying degrees, the ejection fraction (EF%) and minor narrowing rate (FS%) were significantly lower, left ventricular heart coefficient was significantly increased, serum SOD and GSH-Px activity were significantly reduced, the serum levels of MDA and LPO were significantly increased 4 weeks after treatment by Yongmai Yangxin pills. The value of FS%, EF% and SOD activity were increased in varying degrees, the MDA and LPO were reduced in varying degrees. Tongmai Yangxin pills at 2.0, 1.0 g/kg could elevate GSH-Px activity in varying degrees. [Conclusion] Tongmai Yangxin pill has a protective effect against myocardial hypertrophy induced by ISO in rats through enhancing the anti-oxidative activity. |
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