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| Preparation and quality evaluation of tanshinonesⅡA solid lipid nanoparticles |
| Hits 2028 Download times 1224 Received:April 30, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2014.09.16 |
| Key Words
TanshinonesⅡA;solid lipid nanoparticles;quality evaluation |
| Author Name | Affiliation | E-mail | | QU Ji-lan | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory, Tianjin 300193, China | | | LIU Zhi-dong | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory, Tianjin 300193, China | lonerliuzd@163.com | | GUO Xiu-jun | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory, Tianjin 300193, China | | | PANG Xiao-chen | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory, Tianjin 300193, China | | | HAN Zhen-zhen | Tianjin University of Traditional Chinese Medicine, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China
Tianjin University of Traditional Chinese Medicine, Tianjin Modern Chinese Medicine Key Laboratory, Tianjin 300193, China | |
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| Abstract
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| [Objective] To prepare tanshinonesⅡA-loaded solid lipid nanoparticles with docosanoic acid glyceride and glyceryl monos-tearate as its lipid matrix and investigate its quality. [Methods] TanshinonesⅡA-loaded solid lipid nanoparticles were prepared by emul-sion evaporation-solidification. With encapsulation efficiency as index, through the single factor the formulation was optimized, using laser particle size analyzer its particle size was measured, Using potential and use DSC its properties was characterized. [Results] The obtained solid lipid nanoparticles had an average size of (110±4) nm, zeta potential was -38.5 mV and the entrapment efficiency was 79.08%. DSC showed that its physical and chemical properties were stable and reliable. [Conclusion] The solid lipid nanoparticles prepared by the emulsion evaporation-solidification have an appropriate size, the encapsulation efficiency and stable physical and chemical properties have provided an experimental foundation for the development of the new formulation. |
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