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| Prescription compatibility can raise activity of Chinese medicine-An experimental research fromtoxicology |
| Hits 1908 Download times 1307 Received:March 25, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2014.09.17 |
| Key Words
Qingre Jiedu prescription;mixed-decoction;single-decoction;LD50 |
| Author Name | Affiliation | E-mail | | SHI Peng-cheng | Anti tumor drugs R&D Centre, Tianjin Institute of Medical and Pharmaceutical Science, Tianjin 300020, China | | | SHEN Hong-sheng | Anti tumor drugs R&D Centre, Tianjin Institute of Medical and Pharmaceutical Science, Tianjin 300020, China | | | HU Ren-jie | Anti tumor drugs R&D Centre, Tianjin Institute of Medical and Pharmaceutical Science, Tianjin 300020, China | renjiehu@163.com | | YAO Qiang | Tianjin People's Hospital, Tianjin 300121, China | |
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| Abstract
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| [Objective] To compare the effect of toxicity of Qingre Jiedu(clearing heat and detoxification) prescription in different prepa-ration method. [Methods] The drugs contained in Qingre Jiedu prescription were prepared to different samples: single-decoction, mixed-decoction, and single-drug-decoction. The LD50 of each sample after intragastric administration was determined in mice by simplified probit method, and the results were compared. [Results] The LD50 of mixed-decoction and single-decoction samples were (91.26±7.92) g/kg and(111.47±9.12)g/kg respectively. Compared with the mixed-decoction samples, the toxicity of single-decoction samples was de-creased significantly (P<0.05). Different death time and different behaviors before death were fund in animals. Single-drug-decoction sam-ples showed no toxic reaction in most animals after administration. [Conclusion] Compared with single-decoction sample and single-drug-decoction sample, compatible prescription has a certain effect of raising the bioactivity of Chinese medicine. |
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