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| Effectively and systematic review on diabetic retinopathy treated with therapeutic alliance of Laser and compound Xueshuantong capsule |
| Hits 2515 Download times 1830 Received:May 25, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2014.10.04 |
| Key Words
compound xueshuantong capsule;diabetic retinopathy;systematic review;Meta-analysis |
| Author Name | Affiliation | E-mail | | LIN Jia | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | TIAN Ran | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LEI Xiang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Li | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MA Ning | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | SHANG Hong-cai | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | shanghongcai@foxmailcom |
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| Abstract
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| [Objective] To assess the efficacy and safety of diabetic retinopathy treated with therapeutic alliance of Laser and compound Xueshuantong capsule (CXSTC). [Methods] All randomized and quasi-randomized controlled trials (RCTs and quasi-RCTs) on CXSTC for diabetic retinopathy were searched from databases including VIP, Wangfang Data, CNKI, PubMed and the Cochrane Library. The Cochrane Reviewer's Handbook 5.2.8 was used to evaluate the quality of included studies, and the RevMan 5.2 software provided by the Cochrane Collaboration was used for data analyses. [Results] A total of 6 RCTs were included. The quality of the included trials was low. Only one study mentioned the use of random number table for sequence generation. The results of meta-analysis showed that: the improvement in vision[RR=1.20, 95%CI(1.12, 1.28)], alleviation of fundus lesions[RR=1.22, 95%CI(1.14, 1.31)]and of macular oedem[RR=1.33, 95%CI(1.13, 1.58)], as well as the effective rate calculated for enhancement in vitreous opacity and light sensitivity were greater in the CXSTC group than that in the routine therapy group. Adverse reactions caused by CXSTC were reported in 2 studies, which included transient ocular hypertention and persistent macular oedema. No severe adverse reactions were reported. [Conclusion] The currently existing evidence showed that CXSTC may have better effects on diabetic retinopathy when used in combination with routine western therapy, including improving vision, and alleviating fundus lesions and macular oedema. However, because of the low methodological quality of the included trials this conclusion needs to be interpreted with caution and more well-designed, high-quality RCTs need to be performed. |
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