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| Effects of Chinese herbal medicine additives on respiratory and immune function of cigarette-smoking rats |
| Hits 1749 Download times 1632 Received:May 27, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2014.11.11 |
| Key Words
cigarettes;rats;lung function;immune function |
| Author Name | Affiliation | E-mail | | LU Guo-yan | Tianjin Key Laboratory of Chinese medicine Pharmacology, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Yue | Tianjin Key Laboratory of Chinese medicine Pharmacology, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MENG Qing-nai | The Technical Center of Shanghai Tobacco (Group) Company, Shanghai 200082, China | | | ZHENG Sai-jing | The Technical Center of Shanghai Tobacco (Group) Company, Shanghai 200082, China | | | ZHOU Kun | Tianjin Key Laboratory of Chinese medicine Pharmacology, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HU Li-min | Tianjin Key Laboratory of Chinese medicine Pharmacology, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | huliminth@126.com |
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| Abstract
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| [Objective] To evaluate the improving effect of Chinese herbal medicine additives on the respiratory and immune function of cigarette-smoking rats. [Methods] The smoking group was exposed in the flue gas of nose-only system for 1 hour every day, while the control group was exposed in the system without cigarette for 1 hour. Three months later the pulmonary function and the organ coefficient were determined. Taking blood from the abdominal aorta the serum antioxidant and immune factors were measured. [Results] The forced vital capacity of smoking rats was the same with the control group. FEV1/FVC%, however, was declined. Among them, No.3 tobacco group were increased significantly compared with the 0 tobacco group (P<0.05). At the same time, the index of forced expiratory flow 25%~75% (FEF25%~75%), maximal mid-expiratory flow (MMF) and peak expiratory flow (PEF) in No.2 and No.3 tobacco group were improved significantly compared with 0 tobacco group. They were closed to control group. Spleen organ coefficient of 1,3 tobacco group was significantly higher than that of 0 smoke group(P<0.05). No. 2, 3 tobacco group were increased significantly compared with the 0 tobacco group on SOD(P<0.05) without significant difference on MDA. No. 1, 2, 3 tobacco group were higher comparing with 0 tobacco group. The IFN-γ was increased and the IL-1β decreased. No. 1 tobacco group could significantly reduce the IL-6(P<0.001) and No. 3 tobacco group could significantly reduce the IL-12(P<0.05). [Conclusion] No.2,3 additives can effectively inhibit the declining of respiratory function in rats induced by smoking, and protect the oxidative damage. No.1,3 additive can partly improve the immunity of rats caused by smoking. No. 3 additive is the ideal additive for cigarettes. |
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