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| Clinical observation on 60 cases of moderate and severe cancer pain treated by soft firm acetanilide plaster with transdermal fentany |
| Hits 1762 Download times 1559 Received:July 20, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2014.12.06 |
| Key Words
soft firm acetanilide plaster;transdermal fentany;cancer pain;curative effect |
| Author Name | Affiliation | E-mail | | TIAN Yan-ping | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | JIA Ying-jie | The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | jiayingjie1616@sina.com |
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| Abstract
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| [Objective] To investigate the clinical efficacy of soft firm acetanilide plaster combining transdermal fentany on moderate and severe cancer pain. [Methods] One hundred and twenty-two cancer pain patients were randomized divided into two groups according to the random number table, sixty cases and sixty-two cases respectively. In treatment group, patients were treated by soft firm acetanilide plaster combining transdermal fentany; in control group, patients were only treated by transdermal fentany, 7 days for the therapeutic period, and treat for 2 periods. Record mass pain relief, dosage of transdermal fentany, number of breakthrough pain and morphine consumption for breakthrough pain, pain scores with visual analogue scale and Karnofsky performance status(KPS, every 7 days). [Results] The total effective rates of the pain relief has no different(P>0.05) and VAS scores in two groups were better than testing before treating(P<0.05), but there was no different between two groups(P>0.05).But the increase in dosage of transdermal fentany, and the treatment group was lesser than the control group(P<0.05). In KPS, the treatment group was better than that in control group in the 7th day, 14th day(P<0.05). In number of breakthrough pain and morphine consumption for breakthrough pain, the control group was more than testing before treating(P<0.05), and the treatment group was no more than testing before treating(P>0.05). The control group was more than the treatment group(the 7th day) (P<0.05). Two groups were more than testing before treating(P<0.05), but the treatment group was less than the control group(P<0.05, the 14th day). [Conclusion] The efficacy of soft firm acetanilide plaster can decrease the dosage of transdermal fentany and improve quality of life on moderate and severe cancer patients. |
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