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| Research on effect of Zhuanggu Yihao prescription in agalgesia and anti-inflammatory action |
| Hits 1740 Download times 1121 Received:June 14, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2014.12.15 |
| Key Words
Zhuanggu Yihao prescription;analgesia;anti-inflammatory |
| Author Name | Affiliation | E-mail | | ZHONG Wen-jie | Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Zhan-biao | Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | 634256747@qq.com | | WANG An-hong | Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | TIAN Wen-quan | Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To observe the effects of Zhuanggu Yihao prescription in the analgesia and anti-inflammatory action. [Methods] Using the method of mouse hot plate and acetic acid writhing the analgesia of Zhuanggu Yihao prescription was observed; papain was injected into rat's knee joints to establish the animal model of osteoarthritis and to observe the anti-inflammation by Zhuanggu Yihao prescription. [Results] The pain caused by the hot plate was significantly extended in Zhuanggu Yihao prescription of 3.08, 1.54g/kg dose group (60 min, 19.78 s, P<0.05 and 20.56 s, P<0.01), (90 min, 20.67s and 20.56 s, P<0.05), and the number of writhing was reduced in Zhuanggu Yihao prescription of 3.08, 1.54g/kg dose group (P<0.01). Zhuanggu Yihao prescription could obviously reduce the leukocyte count and neutrophil count (P<0.01), and reduce the contents of IL-6 in the soft tissue homogenate(P<0.01)and reduce the contents of IL-6 and PGE2 in synovial fluid(P<0.01). [Conclusion] Zhuanggu Yihao prescription has significant analgesia and anti-inflammatory effect. |
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