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| Correlation research between syndromes of traditional Chinese medicine and levels of adiponectin, leptin, resistin in pre-hypertension |
| Hits 1702 Download times 1614 Received:September 17, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2015.02.03 |
| Key Words
pre-hypertension;syndrome differentiation;adiponectin;leptin;resistin;correlation |
| Author Name | Affiliation | E-mail | | LIU Zhen-yue | Department of Traditional Chinese Medicine, Tianjin Hongqiao Hospital, Tianjin 300131, China | | | ZHANG Jian-zhong | Department of Traditional Chinese Medicine, Tianjin Hongqiao Hospital, Tianjin 300131, China | tjhqyyzhangjz@126.com |
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| Abstract
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| [Objective] To study the levels of adiponectin, leptin, resistin in pre-hypertension and its impact on syndrome differentiation, and to investigate the correlation among the levels of adiponectin, leptin, resistin and age, body mass index, systolic blood pressure, diastolic blood pressure, mean arterial pressure.[Methods] Inclusion diagnosed as pre-hypertensive subjects in 79 cases as the pre-hypertension group, including 20 cases of liver-fire hyperactivity type, 18 cases of Yang hyperactivity and Yin deficiency type, 22 cases of excessive of phlegm-dampness type, 19 cases of Yin-Yang deficiency type, while incorporating 15 cases of healthy subjects with the ideal blood pressure as the control group. The subjects were measured in the levels of adiponectin, leptin, resistin in fasting serum, and statistically analyzed.[Results] 1)The fasting serum adiponectin in pre-hypertension group was significantly lower than that of control group (P<0.01), fasting serum leptin, resistin levels were significantly higher than that in control group (P<0.01). 2) The level of adiponectin in excessive of phlegm-dampness type was lower than the other three types (P<0.05), leptin, resistin levels higher than the other three syndromes (P<0.05), and there was no statistically significant among the types of liver-fire hyperactivity, Yang hyperactivity and Yin deficiency, and Yin-Yang deficiency by pairwise comparisons (P>>0.05). 3)In pre-hypertension group, adiponectin levels was negatively correlated with systolic blood pressure and mean arterial pressure, leptin was positively correlated with systolic, diastolic, and mean arterial pressure, resistin had no significant correlation between these indicators. Leptin in the control group was positively correlated with age, systolic blood pressure, diastolic, and mean arterial pressure, but adiponectin and resistin had no significant correlation between these indicators.[Conclusion] 1) Pre-hypertension group had lower level of adiponectin and higher levels of leptin and resistin than the control group, these levels had varying degrees of correlation with the blood pressure levels, indicating that adipose tissue may be involved in the occurrence of pre-hypertension. 2) The levels of adiponectin in the excessive phlegm-dampness type subjects were lower than other three syndromes, but the levels of leptin and resistin were higher, indicating that the endocrine function of adipose tissue may affect the pre-hypertension traditional Chinese medicine (TCM) syndrome differentiation, these levels may be the objective indicators of pre-hypertension TCM syndrome differentiation. 3)Interference to the endocrine function of adipose tissue may be the effective way of preventing pre-hypertension occurrence and even development into clinical hypertension. |
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