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| Preliminary research on the role of TLR4 at acupoints in the inflammatory reaction produced by acupuncture |
| Hits 1470 Download times 1654 Received:October 14, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2015.02.07 |
| Key Words
acupuncture;acupuncture point;TLR4;inflammatory reaction |
| Author Name | Affiliation | E-mail | | XI Qiang | Experimental Research Center for Acupuncture in Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | CUI Rui | Experimental Research Center for Acupuncture in Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | JIN Guang | Experimental Research Center for Acupuncture in Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GUO Yong-ming | Experimental Research Center for Acupuncture in Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | guoymxr@163.com |
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| Abstract
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| [Objective] To investigate the role of TLR4 at acupoints in the inflammatory reaction produced by acupuncture.[Methods] The 80 health rats were divided into acupuncture group and blank control group, each group 40 rats. Each group was randomly divided into 8 time points(immediate, 15 min, 30 min, 1 h, 2 h, 4 h, 8 h, 24 h), 5 rats per point. Testing the concentrations of TLR4, HMGB1, IL-1α, IL-6, TNF-βin point area including skin and muscle tissue with ELISA. [Results] There were no significant changes in the concentration of each index at each time point in control group. Acupuncture could increase the concentrations of TLR4, HMGB1, IL-6, TNF-β, whereas IL-1αconcentrations did not change. The concentrations of HMGB1, TNF-βhad certain relativity with the concentration of TLR4 respectively after acupuncture. However, the concentration of IL-6 had weaken relativity with TLR4and the concentration of IL-1αhad uncertain relativity with TLR4. [Conclusion] TLR4 located at acupoints may play an important part in the inflammatory reaction produced by acupuncture. |
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