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| Experimental study on compatibility of invigorating kidney herbs and dispelling wind herbs used in lupus mice to control the progress of lupus nephritis |
| Hits 1534 Download times 1605 Received:September 27, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2015.02.09 |
| Key Words
invigorating kidney herb;dispelling wind herb;lupus mice;lupus nephritis |
| Author Name | Affiliation | | WANG Dan | Department of Rheumatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
| | ZHAO Hao | Department of Arthritis Emergency, Guanghua Integrative Medicine Hospital in Changning District, Shanghai 200092, China | | XUE Luan | Department of Rheumatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
| | LIU Ji | Department of Rheumatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
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| Abstract
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| [Objective] To observe the effects of compatibility of invigorating kidney herbs and dispelling wind herbs used in lupus mice. [Methods] Fifty lupus mice were randomly divided into five groups, and they were invigorating kidney group, dispelling wind group, invigorating kidney and dispelling wind group, medicine group and normal saline group. Another 10 BAbl/c mice were used to compare. Each group was given the corresponding herbs and medicine for six weeks. [Results] The weight of the mice in each group increased with weeks growth, the dispelling wind group increased lower significantly than other groups (P<0.05). The level of ds-DNA in groups that given herbs and medicine was lower than in normal saline group (P<0.05). The level of ds-DNA in invigorating kidney and dispelling wind group declined significantly than other groups (P<0.05). The level of IL-17 in groups that given herbs and medicine declined significantly than normal saline group (P<0.05), and the invigorating kidney and dispelling wind group was lower than medicine group which was lower than invigorating kidney group, dispelling wind group, but no difference among each group. There were seven mice of normal saline group occurred erythrocytes in urine which was more than other groups, but no difference among each group(P>>0.003 12). All the mice of normal saline group appeared urinary protein which were more than other groups (P<0.003 12) and there was no difference between the groups except normal saline group (P>>0.003 12). [Conclusion] Compatibility of invigorating kidney herbs and dispelling wind herbs can control the development of lupus nephritis through the way of declining the expression of IL-17 and ds-DNA in Lupus Mice significantly, which effects were better than using invigorating kidney herbs or dispelling wind herbs alone. |
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