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| Effect of the extract of Ginkgo Biloba in brain tissue morphology in rabbit hypercholesteremia model |
| Hits 1973 Download times 1655 Received:November 03, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2015.03.09 |
| Key Words
extract of Ginkgo Biloba;hypercholesteremia;nerve fiber |
| Author Name | Affiliation | E-mail | | GAO Qing | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MA Dong-ming | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HU Xian-tong | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LU Bin | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Rui-feng | Department of Pathology, Xintai Hospital of Traditional Chinese Medicine, Xintai 271200, China | | | FENG Yu-tao | Department of Traditional Chinese Medicine, Affiliated Hospital of Tianjin Armed Police Logistics College, Tianjin 300162, China | | | JIANG Xi-juan | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | xijuanjiang@foxmail.com |
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| Abstract
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| [Objective] To study the effect of the extract of Ginkgo Biloba 761(EGB 761) on brain tissue morphology in rabbit hypercholesteremia model. [Methods] We built the hypercholesteremia model with male New Zealand white rabbits, which were divided into four groups: the control group, the model group, the simvastatin group, the EGB761 group. Detecting the morphology change of nerve fiber with HE staining and silver staining. [Results] The hippocampus in model group showed neuronal degeneration, necrosis and microfibers tangles while the EGB761 group showed less neuronal degeneration, necrosis and microfibers tangles, and regular nuclear morphometry. [Conclusion] EGB761 can effectively protect the integrity of the structure of nerve fibers in hypercholesterolemia. |
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