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| Current opinion in G protein coupled receptor dimers pharmacology |
| Hits 1644 Download times 1952 Received:November 05, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2015.03.14 |
| Key Words
G protein coupled receptor;dimerization;signal transduction |
| Author Name | Affiliation | E-mail | | ZHANG Xi-ting | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | DONG Peng-zhi | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | pengzhiryn@163.com | | TAN Xiao-wen | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Ying | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHU Yan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | yanzhu.harvard@gmail.com |
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| Abstract
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| G protein coupled receptor (GPCR), expressed in almost every single cell, undertake a variety of physiological and pathological role. In recent years, a growing number of studies have shown that these receptors are involved in regulating the physiological activities in the form of dimer, play an important role in signal recognition and transduction leading to physiological changes and diseases treatment which provide a new target for drugs. Now with the development of biotechnology and molecular biology, the dimerization of GPCR research has made great progress. This article aims to summarize the progress of studies on the physiological and pathological effects of GPCR dimerization. |
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