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| Effect of Huazhuo Xingxue grains on inflammatory factor in the common carotid artery of atherosclerosis rats |
| Hits 1611 Download times 1505 Received:September 28, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2015.04.08 |
| Key Words
Huazhuo Xingxue grain;atherosclerosis;peroxisome proliferator-activated receptor;nuclear factor kappa B |
| Author Name | Affiliation | E-mail | | ZHOU Yong-hong | Department of Traditional Chinese Medicine, Medical College of Qingdao University, Qingdao 266021, China | | | HU Huai-qiang | Department of Neurology, The General Hospital of Jinan Military Command, Jinan 250031, China | huhuaiqiang@126.com | | ZHANG Hao | Department of Traditional Chinese Medicine, Medical College of Qingdao University, Qingdao 266021, China | |
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| Abstract
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| [Objective] To explore the effect of Huazhuo Xingxue grains on peroxisome proliferator-activated receptor (PPAR) and nuclear factor kappa B (NF-κB) in the common carotid artery of atherosclerosis rats. [Methods] The rats were randomly divided into control, model, and medicine groups. The medicine group was administrated with Huazhuo Xingxue grains for a course of 8 weeks after the atherosclerosis model rats were established by high fat diet, the control group and model group were taken oral equivolumetric distilled water. PPAR mRNA was measured by real time PCR, NF-κB was measured by western blotting. [Results] The PPARα, PPARβ and PPARγ of model group obviously decreased, NF-κB of model, medicine groups obviously increased, which were significantly difference with the control group (P<0.01). The PPARα, PPARβ and PPARγ of medicine group obviously increased, which were significantly difference with the model group (P<0.01). NF-κB of medicine group was significantly less than those of model group(P<0.01). [Conclusion] Huazhuo Xingxue grains can active PPARα, PPARβ and PPARγ and resist NF-κB to inhibit the development of atherosclerosis. |
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