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| Influence of Ziqi Jiangtang Yin to type 2 diabetes mellitus rats insulin resistance and adipocytokines |
| Hits 1777 Download times 1821 Received:December 20, 2014 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2015.04.09 |
| Key Words
T2DM;insulinresistance;experiment research;adipocytokines;Zhiqi Jiangtang Yin |
| Author Name | Affiliation | E-mail | | LIU Jia | Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China | | | WANG De-hui | Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China | wangdh2004@sina.com | | LI Jin-hong | Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China | | | DU Rui-bin | Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China | | | WANG Hai-ying | Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China | | | LI Chun-ling | Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China | | | HU Li-ping | Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China | | | ZHANG Xiao-li | Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China | | | FU Li-yan | Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China | | | ZHANG Li-wei | Department of Endocrinology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medictne, Tianjin 300150, China | |
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| Abstract
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| [Objective] To discuss the action mechanism of Zhiqi Jiangtang Yin, which from The old doctor of traditional Chinese medicine experience formula, improving insulin resistance of type 2 diabetes rats.[Methods] To build type 2 diabetes rat model of insulin resistance, feeding 50 SD rats with high sugar high fat diet for 4 weeks later,giving the low-dose injection of streptozotoein. Detect rats fasting blood glucose (FBG), fasting insulin (FINS), blood lipid (TC, TG, HDL, LDL) levels, insulin sensitive index (ISI), indexes of insulin resistance (HOMA IR), evaluate its influence on glyco-lipid metabolism in type 2 diabetes insulin resistance. Detect rats serum adipocyte factor levels, including adiponectin, TNF-α, resistin, FFA, and observe each group of rats pancreatic pathological changes. To discuss the action mechanism of Zhiqi Jiangtang Yin improving insulin resistance and increasing insulin sensitivity of type 2 diabetes rats. [Results] Zhiqi Jiangtang Yin high and low dose group both can regulate blood sugar and serum insulin levels, improve the ISI, lower HOMA-IR.Can regulate blood lipid disorders, increase serum adiponectin levels, reduce serum FFA, TNF alpha, resistin level, improve and repair on pancreatic pathological changes, compared with the model group had significant difference (P<0.05). [Conclusion] Zhiqi Jiangtang Yin has great therapeutic effect to type 2 diabetes rats of insulin resistance. It is safety and reliable, which worthy of clinical promotion. |
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