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| Research on quality standards and pharmacological effects of Qingre Zhike oral liquid |
| Hits 1681 Download times 1261 Received:December 18, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2015.04.12 |
| Key Words
Qingre Zhike oral liquid;quality standard;radix peucedani;pharmacological effect |
| Author Name | Affiliation | E-mail | | REN Rong | General Hospital of Tianjin Medical University, Tianjin 300052, China | | | CHEN Guan | Tianjin Institute of Medical Sciences, Tianjin 300020, China | | | LI Zheng-xiang | General Hospital of Tianjin Medical University, Tianjin 300052, China | lee41@sina.com |
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| Abstract
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| [Objective] To establish quality standard and evaluate the pharmacodynamic effects of Qingre Zhike oral liquid. [Methods] TLC method was used to identify Pericarpium Trichosanthis and Prunus Armeniaca in Qingre Zhike oral liquid. The contents of Praeruptorin A and Praeruptorin B were determined by HPLC. The cough settling effect was observed on the ammonia water induced cough model of mouse. [Results] Established TLC had clear spots without interference of the negative control sample. Linear ranges of Praeruptorin A and Praeruptorin B were 10.20~102.00 μg/mL and 3.96~39.60 μg/mL, average recoveries were 98.94%(RSD 1.39%) and 99.74% (RSD 1.75%), respectively. High dose and middle dose group of Qingre Zhike oral liquid could produce a protective effect on the cough induced by ammonia (P<0.05). [Conclusion] The method is simple, rapid, reproducible and specific, and it can be used for the quality control of Qingre Zhike oral liquid. Qingre Zhike oral liquid has the anti-cough effect. |
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