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| Development in reversing mechanism of MCF-7/ADM cell multidrug resistance by traditional Chinese medicine |
| Hits 1703 Download times 1804 Received:December 19, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2015.04.15 |
| Key Words
traditional Chinese medicine;MCF-7/ADM cell;multidrug resistance;P-gp |
| Author Name | Affiliation | E-mail | | ZENG Qing-qing | Modern Key Laboratory in Tianjin, Key Laboratory Breeding Base of State Constructed by Provincial Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China | | | WANG Peng | Modern Key Laboratory in Tianjin, Key Laboratory Breeding Base of State Constructed by Provincial Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China | | | PAN Gui-xiang | Modern Key Laboratory in Tianjin, Key Laboratory Breeding Base of State Constructed by Provincial Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | guixiangp@163.com | | WANG Xiao-ming | Modern Key Laboratory in Tianjin, Key Laboratory Breeding Base of State Constructed by Provincial Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Chun-hua | Modern Key Laboratory in Tianjin, Key Laboratory Breeding Base of State Constructed by Provincial Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| Chemotherapy failure of antitumor drugs in clinical was mainly caused by multidrug resistance (MDR) of breast cancer cells (MCF-7/ADM). P-gp、Bcl-2、GST-π、TopoⅡand other proteins may be associated with the multi-drug resistance of breast cancer. In recent years, many traditional Chinese medicine were found that they can reduce the expression of MDR1 mRNA and/or P-gp protein, thereby reversing the multi-drug resistance of tumor drugs against human breast cancer cells and increase their chemosensitivity to chemotherapeutic drugs. Therefore, the summary is about resistance mechanisms of MCF-7/ADM and traditional Chinese medicines which can reverse multi-drug resistance of breast cancer cells. |
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