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| Effects of Jintiange capsules in treating fracture healing and in microstructure of bone in rats |
| Hits 1372 Download times 1751 Received:December 20, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2015.05.09 |
| Key Words
traditional Chinese medicine;fracture;animal model;Micro-CT;treatment |
| Author Name | Affiliation | E-mail | | ZHANG Wei-ran | Orthopedic Department, Tianjin Gong'an Hospital, Tianjin 300042, China
Foot and Ankle Institute, Tianjin Gong'an Hospital, Tianjin 300042, China | | | LU Jun | Orthopedic Department, Tianjin Gong'an Hospital, Tianjin 300042, China
Foot and Ankle Institute, Tianjin Gong'an Hospital, Tianjin 300042, China | junlu0419@163.com | | SONG Dong-hui | Orthopedic Department, Tianjin Gong'an Hospital, Tianjin 300042, China
Foot and Ankle Institute, Tianjin Gong'an Hospital, Tianjin 300042, China | | | ZENG Xian-fan | Orthopedic Department, Tianjin Gong'an Hospital, Tianjin 300042, China
Foot and Ankle Institute, Tianjin Gong'an Hospital, Tianjin 300042, China | | | WANG Wei | Orthopedic Department, Tianjin Gong'an Hospital, Tianjin 300042, China
Foot and Ankle Institute, Tianjin Gong'an Hospital, Tianjin 300042, China | | | YANG Jie | Orthopedic Department, Tianjin Gong'an Hospital, Tianjin 300042, China
Foot and Ankle Institute, Tianjin Gong'an Hospital, Tianjin 300042, China | |
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| Abstract
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| [Objective] To evaluate the effects of Jintiange capsule in treating fracture healing in rats. [Methods] The 40 Spragu-Dawley rats were divided into two groups randomly. Left femoral shaft fractures were created in all rats closely, and treated with intramedullary nail. The rats of experimental group were administrated with Jintiange capsule. The rats of control group were given water. The rats were sacrificed at 2 and 8 weeks. Parameters of callus in two groups were evaluated by Micro-CT. Endura TEC ELF 3200 mechanical testing machine was used to evaluate the biomechanical effect of fractured femoral shaft. Moreover, the fracture healing was also evaluated by X-ray. [Results] At 2 and 8 weeks, there was no significant difference in fracture healing evaluated by X-ray between two groups. The total volume (TV) in callus in experimental group was higher than control group in 2 weeks, but no difference in bone volume(BV), BV/TV and biomechanical property. At 8 weeks, the experimental group was significant in BV, BV/TV and biomechanical property compared with control group, but not in TV. [Conclusion] Jintiange capsule can enhance the fracture healing in rats by increasing callus formation in early phase and improving mineralization in later phase. |
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