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| The synergy between Xinfukang and Bone marrow mesenchymal stem cells increases the expression of GATA4 and Cx43 in cardiac stem cells |
| Hits 1630 Download times 1775 Received:December 18, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2015.05.10 |
| Key Words
Xinfukang;bone marrow mesenchymal stem cell;cardiac stem cell;GATA4;Cx43 |
| Author Name | Affiliation | E-mail | | WANG Yi-jing | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | SUO Yan-rong | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZENG Wen-yun | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | KAN Bo-hong | The First Affiliated Hospital of Traditional Chinese Medicine, Tianjin 300193, China | | | JIANG Xi-juan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | FAN Ying-chang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | fych@tjutcm.edu.cn |
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| Abstract
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| [Objective] To observe the synergy effects between Xinfukang and Bone marrow mesenchymal stem cells(BMSC) in the expression of GATA4 and Cx43 in Cardiac stem cells(CSC). [Methods] BMSC were obtaining by the whole bone marrow adherent method, and the purity was evaluated by flow cytometry. Xinfukang convalescent serum were analyzed through high performance liquid chromatography(HPLC), and then used for cell co-culture system. Real-time quantitative PCR were used to detect the expression of GATA4 and Cx43 in groups of CSC. [Results] GATA4 and Cx43 in the Xinfukang group were increased significantly(P<0.05). [Conclusion] Xinfukang collaborative with BMSC can increase the expression of GATA4 and Cx43in CSC. |
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