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| Research of the solubilization of glycyrrhizic acid to puerarin |
| Hits 1595 Download times 1565 Received:November 21, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2015.05.13 |
| Key Words
glycyrrhizic acid;puerarin;solubilization;HPLC;surface tension;pH value |
| Author Name | Affiliation | E-mail | | YANG Xuan | School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | WANG Yan | School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | WANG Bao-hua | School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | wbaohua1@163.com | | SHI Xin-yuan | School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | LU Bing | School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | SHAO Lu | School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | LI Ping | School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | YANG Bei-bei | School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | |
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| Abstract
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| [Objective] To calculate the critical micelle concentration of glycyrrhizic acid and explore the solubilizing mechanism of glycyrrhizic acid to puerarin, by measuring the amount of puerarin and glycyrrhizic acid and the surface tension of solution in single decoction of pueraria and glycyrrhiza and their mixed decoction of different proportions. [Methods] The HPLC procedure was performed for measuring the amount of puerarin and glycyrrhizic acid, and the surface tension of solution was measured by Wilhelmy plate method. [Results] When the ratio of pueraria and glycyrrhiza was 5:3, the dissolution of puerarin reached maximum, and the critical micelle concentration of glycyrrhizic acid was 0.18 g/L, which was affected by the structure of drug and the pH value of solution.[Conclusion] Glycyrrhizic acid has surface activity, and it can increase the solubility of puerarin when its concentration reaches the critical micelle concentration. |
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