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| Myocardial protection of Shenmai injection on acute myocardial infarction in rats |
| Hits 1327 Download times 1452 Received:January 11, 2015 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2015.06.08 |
| Key Words
Shenmai injection;myocardial infarction;myocardial protection |
| Author Name | Affiliation | E-mail | | ZHU Li-jie | Research Institute of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | CHEN Jing-rui | Research Institute of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GONG Bo | Research Institute of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | FAN Guan-wei | Research Institute of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | fgw1005@hotmail.com |
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| Abstract
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| [Objective] To study the protective effect of Shenmai injection on myocardial infarction of rats. [Methods] Construction of rat myocardial infarction model using coronary artery ligation. Detected by echocardiography and Doppler blood flow, determination of serum creatine kinase(CK), creatine kinase(CK-MB), lactate dehydrogenase (LDH), superoxide dismutase(SOD) and malondialdehyde(MDA) activity change; combined with HE staining Pathological analysis, comprehensive evaluation of the protective effect of Shenmai injection on myocardial infarction. [Results] Shenmai injection can significantly improve left ventricular function and cardiac blood supply function after myocardial infarction, reducing myocardial tissue lesions, including the reduction of inflammatory infiltration, reduction of myocardial fibrosis, and reduce CK, LDH, MDA levels, increase the activity of SOD. [Conclusion] Shenmai injection has a protective effect on myocardial infarction of rats. |
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