|
| Study of therapeutic effect of Rehmaniae Radix Polysaccharide on diabetic nephropathy rats and the role of RAGE/NF-κB signaling pathway |
| Hits 1353 Download times 1369 Received:January 20, 2015 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2015.06.12 |
| Key Words
Rehmaniae Radix Polysaccharide;diabetic nephropathy;anti-inflammatory;RAGE;NF-κB |
| Author Name | Affiliation | E-mail | | KANG Wei | Department of Endocrinology, Tianjin Fifth Central Hospital, Tianjin 300071, China | | | XU Yan-ying | The Second Affiliated Hospital of Tianjin Medical University, Tianjin 300150, China | xuyanying_2010@126.com |
|
| Abstract
|
| [Objective] To investigate the therapeutic effect of Rehmaniae Radix Polysaccharide on diabetic nephropathy rats and the role of RAGE/NF-κB signaling pathway. [Methods] Diabetic nephropathy rats induced by STZ were randomly divided into five groups (n=10): control group, diabetic nephropathy group, low Rehmaniae Radix Polysaccharide group, middle Rehmaniae Radix Polysaccharide, and high Rehmaniae Radix Polysaccharide group. The effects of Rehmaniae Radix Polysaccharide on body weight, FBG, FINS, 24 h urine volume and urine protein were investigated. Moreover, Western Blot was applied for evaluating the expression of RAGE and NF-κB protein. [Results] Rehmaniae Radix Polysaccharide could increase the body weight, reduce the content of FBG, enhance FINS level. Meanwhile, serum creatinine, blood urea nitrogen, 24 h urine volume and urine protein of diabetic nephropathy rats were also decreased after Rehmaniae Radix Polysaccharide treatment. Furthermore, Rehmaniae Radix Polysaccharide showed an obvious anti- inflammatory effect through increasing the expression of RAGE and NF-κB in kidneys. [Conclusion] These results indicated Rehmaniae Radix Polysaccharide could provide protection effect on diabetic nephropathy rats through hpyerglycemic and anti-inflammatory, which is related to RAGE/NF-κB signaling pathway. |
|
|
|
|
|
|
|
