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| Preparation of acteoside solid lipid nanoparticle and the in vitro release characteristics |
| Hits 1351 Download times 1316 Received:December 27, 2014 |
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| DOI
10.11656/j.issn.1672-1519.2015.06.13 |
| Key Words
acteoside;solid lipid nanoparticle;entrapment efficiency;stability;in vitro release |
| Author Name | Affiliation | E-mail | | TONG Ling | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Zhi-bao | Tongyao Pharmaceutical Group Stock Co., Ltd., Tonghua 134000, China | | | CHEN Jing | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Zhi-dong | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | lonerliuzd@163.com | | ZHANG Li | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Bao-cheng | Tongyao Pharmaceutical Group Stock Co., Ltd., Tonghua 134000, China | |
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| Abstract
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| [Objective] To study the preparation of acteoside solid lipid nanoparticle(SLN) and its in vitro release behavior. [Methods] Emulsification-evaporation was appropriate for the preparation of acteoside solid lipid nanoparticle and entrapment efficiency was measured by ultrafiltration. The properties of SLN including mean diameter and Zeta potential were studied. The physical property was measured by DSC and the release property was studied by dialysis method. [Results] Mean diameter and Zeta potential of prepared acteoside solid lipid nanoparticle were 85.56 nm and -20.97 mV. The mean drug entrapment efficiency was 88.31%. The physical property tested by the result of DSC was stability, and the in vitro accumulative release was 62.46% of the total drug. [Conclusion] The acteoside SLN prepared in this study has high encapsulation efficiency and small size which has an even distribution and the in vitro release could be in a well sustained way. |
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