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| Study of the inhibition effect and mechanism of Xiaoyan decoction and decomposed recipe on A549 cells in vitro |
| Hits 2034 Download times 1739 Received:February 14, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2015.07.11 |
| Key Words
Xiaoyan decoction;A549 lung adenocarcinoma cancer cell;inhibition in vitro |
| Author Name | Affiliation | E-mail | | LI Xiao-jiang | Oncology Department, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | JIA Ying-jie | Oncology Department, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | zxqlovelxj@126.com | | YU Jian-chun | Oncology Department, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Xiao-qing | Oncology Department, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | DU Xiao-ling | The College of Life Sciences, Nankai University, Tianjin 300071, China | | | Zhu Jin-li | Oncology Department, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MENG Xing | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To investigate the inhibition of Xiaoyan decoction and decomposed recipe on A549 in vitro and its possible mechanism. Explore the most effective composition and concentration of Xiaoyan decoction. [Methods] According to the effect, Xiaoyan decoction was divided into three groups: Qingre Jiedu group, Huoxue Huayu group and Yiqi Fuzheng group. Use CCK 8 method to detect proliferation activity of A549 lung adenocarcinoma cancer cells. [Results] Groups had obvious inhibitory effect of cancer cell activity. The inhibition of strength in the order was Xiaoyan decoction group, Qingre Jiedu group, Huoxue Huayu group and Yiqi Fuzheng group. [Conclusion] Xiaoyan decoction and decomposed recipe groups have obvious inhibitory effect on A549 cells activity. Xiaoyan decoction (50 g/L) shows more inhibition on A549 cells with the lowest cell viability and is time-dependent. Effect of Qingre Jiedu group is close to Xiaoyan decoction, and suggests that Qingre Jiedu group is the most effective components for anti-tumor effect of the experiment in vitro of Xiaoyan decoction. |
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