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| Effect of acupoint application of Kechuan plaster on pharmacokinetics of aminophylline in asthmatic guinea pigs |
| Hits 1708 Download times 1537 Received:February 03, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2015.07.12 |
| Key Words
Kechuan plaster;asthma;guinea pig;aminophylline;pharmacokinetics |
| Author Name | Affiliation | | XU Xin | Tianjin Police Hospital, Tianjin 300042, China | | SHEN Jun | Tianjin Medical University, Tianjin 300070, China | | XIONG Xiang-ming | Tianjin Police Hospital, Tianjin 300042, China | | ZHANG Xiu-li | Tianjin Police Hospital, Tianjin 300042, China | | GUO Yu-li | Tianjin Police Hospital, Tianjin 300042, China |
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| Abstract
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| [Objective] To investigate the effect of acupoint application of Kechuan plaster on pharmacokinetics of aminophylline in asthmatic guinea pigs, and to explore its possible mechanism. [Methods] The 30 guinea pigs were assigned to 5 groups randomly, respectively as the normal group, model control group, Kechuan plaster high dose group, medium dose group and low dose group, 6 guinea pigs in each group. Except the normal group, all the other 4 groups were injected into the abdominal cavity with OVA to induce allergy reaction, then inhaled OVA for excitation to prepare the asthma model groups. All guinea pigs were fed aminophylline by gavage, Kechuan plaster high, medium and low dose group was treated with Kechuan plaster acupoint application according to different dosage. Blood was taken by inner canthus puncture, according to the set time point. Plasma concentration of aminophylline was detected by HPLC. DAS2.0 software was used to calculate the pharmacokinetics parameters of aminophylline. [Results] Compared with normal group, model control group and low dose group, plasma half-life of aminophylline extended(P=0.007, P=0.022, P=0.028)and elimination rate constant decreased(P=0.005, P=0.012, P=0.015) in high dose group. Compared with normal group, plasma half-life of aminophylline extended(P=0.029)and elimination rate constant decreased(P=0.047)in medium dose group. [Conclusion] Kechuan plaster acupoint application can affect the pharmacokinetics of aminophylline, and it can extend the plasma half-life and decrease the elimination rate constant. The effect of Kechuan plaster could be controlled by changing the drug particles' diameter. |
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