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| Clinical value of β2-MG, homocysteine and traditional Chinese medicine pulse conditions in early diagnosis of diabetic nephropathy |
| Hits 1431 Download times 2779 Received:March 23, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2015.08.07 |
| Key Words
diabetic nephropathy;β2 microglobulin;homocysteine;TCM pulse conditions;early diagnosis |
| Author Name | Affiliation | E-mail | | ZHOU Sheng-yuan | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | | | LIU Yue | Tianjin People's Hospital, Tianjin 300121, China | | | HOU Chang-qing | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | | | GAO Chang-bai | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | | | FU Li-yan | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | | | MENG Xiang-zhen | The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | mengxz6033@163.com |
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| Abstract
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| [Objective] To evaluate the clinical value and specificity of serum Beta 2 microglobulin(β2-MG), homocysteine (Hcy) and traditional chinese medicine(TCM) pulse conditions in early diagnosis of diabetic nephropathy. [Methods] A prospective study was performed. Patients were consecutively collected from April 2013 to October 2014 according to the urinary albumin excretion rate(UAER) for the diagnosis of DN, and 450 patients admitted to medical ward were divided into three groups. Patients whose UAER<20 μg/min belonged to normal albuminuria(NA) group(176 cases).The ones whose UAER from 20 to 200 μg/min belonged to large albuminuria(MA) group(182 cases),and the others whose UAER ≥200 μg/min belonged to large albuminuria(LA) group(92 cases).The clinical characteristics were then compared. The concentration of serum β2-MG and Hcy in each group was measured. The general data of patients were taken. TCM pulse conditions of patients were acquired in quiet state, and then the value of each index in early diagnosis of DN was analyzed with receiver operating characteristic (ROC) curve. [Results] The serum concentration of β2-MG, Hcy exhibited a gradual increase with the aggression of the disease, and the median β2-MG, Hcy value was highest in the LA group compared with NA group and MA group;the patients with thready pulse or sunken pulse on chi pulse-taking was highest in the LA group compared with NA group and MA group. It was found through the ROC curve analysis of β2-MG, Hcy in the DN patients that the area under the ROC curve for β2-MG (0.768), for Hcy(0.797). The ROC curve analysis combined β2-MG with Hcy was better (0.827), If Combined with pulse, the ROC curve was best (0.866). [Conclusion] Serum levels of β2-MG, Hcy could be employed as biomarkers in the diagnosis and severity assessment of DN. And if the two indicators were tested at the same time, it can improve the accuracy of diagnosis of early DN, and if pulse conditions was combined , it can enhance the Credibility of diagnosis. |
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