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| Effects of Storax on focal cerebral ischemia in rats |
| Hits 1705 Download times 1411 Received:March 15, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2015.08.14 |
| Key Words
Storax;pharmacologic preconditioning;focal cerebral ischemia;safety evaluation;efficacy evaluation |
| Author Name | Affiliation | E-mail | | ZHOU Min | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Graduate School of China Academy of Chinese Medical Science, Beijing 10070, China | | | ZHAO Pei | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHU Jin-qiang | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Xiao-ying | Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA | | | ZHENG Meng | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Bo-li | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Graduate School of China Academy of Chinese Medical Science, Beijing 10070, China | zhangbolipr@163.com |
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| Abstract
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| [Objective] To investigate effects of Storax on acute focal cerebral ischemia in rats. [Methods] Healthy male SD rats were administered intragastrically with Storax at the dose of 0.1, 0.2, 0.4, 0.8 and 1.6 g/kg in each day, for 5 days, and then induced with occlusion of middle cerebral artery (MCAO) with suture embolus. Body weight and hepatic-renal function of healthy rats during pretreatment were measured before stroke, and ischemic infarct volumes and hemispheric swelling rates were quantified on TTC-stained brain slices at 24 h, after stroke, also, neurological scores, death rates and the content of Fib, PT, APTT, TT were evaluated 24 hours after stroke. [Results] Rats treated with storax at the dose of 1.6 g/kg in each day presented signs of toxicity, weight growth were decreased and ALT, CREA were increased compared with other groups (P<0.05), and 0.1, 0.2, 0.4, 0.8 g/kg in each day were chosen as the relatively safety doses to proceed the subsequent experiment. 24 hours after stroke, the infarct volumes, hemispheric swelling rates and neurological deficits of rats in the vehicle group were significant compared with the sham group (P<0.05), and Storax significantly attenuates the brain damage of cerebral ischemia (P<0.05). Compared with the sham group, the concentration of Fib significantly increased (P<0.05) and PT, APTT, and TT significantly shortened in the model group (P<0.05);however, compared with the vehicle group, Storax significantly decreased Fib content (P<0.05) and prolonged PT, APTT (P<0.05). [Conclusion] Storax can attenuate the brain damage and regulate the coagulation function in acute focal cerebral ischemia in rats. |
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