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| Influence of antibiotics transshipment in the lung tissue and therapeutic evaluation of clearing away heat and dispersing phlegm in AECOPD syndrome of phlegm and heat |
| Hits 1441 Download times 2677 Received:April 28, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2015.09.03 |
| Key Words
clearing away heat and dispersing phlegm;antibiotic;acute exacerbation of chronic obstructive pulmonary disease with syndrome of phlegm and heat;transshipment in the pulmonary tissue;therapeutic evaluation |
| Author Name | Affiliation | | LI Jie | Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China | | WANG Lin-yang | Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China | | YAO Xing-wei | Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China |
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| Abstract
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| [Objective] To study the influence of antibiotics transshipment in the lung tissue,mechanism and therapeutic evaluation of clearing away heat and dispersing in acute exacerbation of chronic obstructive pulmonary disease(AECOPD). [Methods] All 65 patients of AECOPD were randomly divided into the treatment group and control group. All were given the therapies of anti-infection, anti-asthma and even mechanical ventilation when necessary. The treatment group was then given the Chinese herbal compound formula orally, control group was given mucosolvan injection (30 mg intravenation) twice a day for one week. The symptoms, chart of CAT, density of antibiotics in deep sputum, content neutrophil elastase(NE) in blood were observed before and after treatment. [Results] 1)Clinic symptom: two groups had no statistical difference in the efficiency of and treatment. There was significant difference in the change of all symptoms and main symptoms at the seventh day of treatment(P<0.05), and treatment group was better than the control group, while no significant difference in fourth days. About the single symptom, the improvement of cough and expectoration quantity had significant difference compared with the control group(P<0.05), and about the comparison on expectoration difficulty and chest tightness improvement, the control group was excellent(P<0.05). There was significant difference between two groups in CAT chart, and better of that in treatment group(P<0.05). 2)Density of antibiotics in deep sputum: drug concentration between two groups had no significant difference, but the treatment group had higher median than the control group. 3)NE:there was no statistical difference in the two groups, and both of them to some extent reduced the level of NE after treatment. [Conclusion] Chinese medicine and ambroxol have potential trend to improve drug concentration in the local tumor tissue. The mechanism that may influence NE to reduce mucus secretion, ease obstruction in airway so as to promote mutually spread of antibiotics in the pulmonary tissue. Moreover, both of them can improve symptoms of AECOPD patients, especially in single symptoms they have their own advantages. Chinese medicine also can improve the quality of life of patients after one week of treatment. |
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