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| Effect of Rongchang capsules on expressions of NRSF and BDNF in hippocampus of epilepsy rats |
| Hits 1665 Download times 1605 Received:April 26, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2015.09.12 |
| Key Words
epilepsy;hippocampus;Rongchang capsule;brain derived neurotrophic factor;neuronal restricted silencing factor |
| Author Name | Affiliation | E-mail | | YANG Chang-quan | The First Affilited Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Wei | The First Affilited Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MA Rong | The First Affilited Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | mr1974@163.com |
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| Abstract
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| [Objective] To explore the effect of Rongchang capsules(RCC) on the protein expression of neuronal restricted silencing factor(NRSF) and brain-derived neurotrophic factor(BDNF) in hippocampus after pentylenetetrazole(PTZ)induced epileptic seizure in young rats. [Methods] To establish the PTZ kindling model of epilepsy, the rats were randomly divided into normal group, model group, valproic acid sodium(VPA)group and RCC low, middle, high dosage group. The expression of NRSF protein and BDNF protein were detected by the Western blot hybridization assay. [Results] The expression of NRSF protein and BDNF protein in hippocampus of rats in model groups were significantly higher than those in the blank group, and the difference was statistically significant (P<0.05). Each treat group could reduce the expression, but RCC high dose group was better than VPA and RCC low, middle dosage group(P<0.05). [Conclusion] The mechanism of RCC antiepilepsy and improvement cognitive impairment after epilepsy may be related to the inhibition of NRSF and BDNF protein expression in juvenile rat hippocampus after epilepsy. |
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