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| Experimental research of hyperuricemia animal models |
| Hits 1628 Download times 2176 Received:May 13, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2015.10.09 |
| Key Words
hyperuricemia;animal model;yeast extract |
| Author Name | Affiliation | E-mail | | MENG Xiao-wei | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | FAN Ke-tao | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | DAI Xiang-dong | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Yi | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | vip_wangyi@126.com |
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| Abstract
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| [Objective] Preparation of stable and sustainable, simple animal model of hyperuricemia. [Methods] Using a simple oteracil potassium, oteracil potassium + hypoxanthine, adenine + ethambutol, pure yeast extract, yeast extract + adenine, adenine + yeast extract + oteracil potassium different drugs and different concentrations to experiment and detecting model animal serum uric acid levels. [Results] Simple oteracil potassium, potassium oxonate + hypoxanthine, model group increased uric acid levels, there were differences compared with the control group, but the larger model is unstable, poor reproducibility, individual differences. Adenine + ethambutol, pure yeast extract and yeast extract + adenine , there was no difference between the model group and control group uric acid levels. Yeast extract + adenine + oteracil potassium increased uric acid levels in the model group, the control group there was a significant difference (P<0.01), and the model was stable, small individual differences. [Conclusion] Using yeast extract + adenine + oteracil potassium can copy best hyperuricemic model. |
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