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| Study on preparation of glabridin hydroxypropyl -β -cyclodextrin inclusion compound and its effect of transdermal absoption |
| Hits 2236 Download times 1878 Received:May 14, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2015.10.11 |
| Key Words
glabridin;HP-β-CD;transdermal absoption |
| Author Name | Affiliation | E-mail | | YE Liu-qing | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Yan | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | paozhijiaoxue@126.com | | HAN Wan-ying | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHOU Xiao-xia | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MA Zong-wu | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | GUI Guang-zhi | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To optimize the preparation technology of glabridin hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion compound and investigate its effect of transdermal absoption. [Methods] With inclusion efficiency as the indice, the optimum preparation condition was studied by orthogonal test. Franz vertical diffusion cell was adopted to investigate transdermal performance of glabridin HP-β-CD. [Results] The optimal inclusion conditions were as follows: the ratio of glabridin to HP-β-CD was 1∶15 (m/m), inclusion temperature was 40 ℃, inclusion time was 1.5 h. The cumulative permeation of glabridin HP-β-CD was higher than glabridin group. [Conclusion] HP-β-CD have significant effect on transdermal of glabridin. |
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