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| Effects of “Qipiyin” decoction on the contents of beta-endorphine in different tissues on the rat model with psoriasis-like lesion |
| Hits 4297 Download times 1444 Received:June 04, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2015.11.10 |
| Key Words
psoriasis;Chinese drug;Qipiyin;beta-endorphine |
| Author Name | Affiliation | E-mail | | YANG Jia-yue | Tianjin Fourth Centre Hospital, Tianjin 300140, China | | | LI Jing | Tanjin Women and Children's Health Center, Tianjin 300070, China | | | WANG Chao | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LAN Feng-rong | Tanjin Women and Children's Health Center, Tianjin 300070, China | | | XU Li-min | Changzheng Hospital of Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China | lijing_med@163.com |
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| Abstract
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| [Objective] To study on the influence of Chinese drug Qipiyin on the rat model with psoriasis-like lesion and the contents of beta-endorphine in different tissues. [Methods] The rat model with psoriasis-like lesion were prepared, and they were treated with Chinese drug once each day. After treatment of 10 days, changes of the skin histopathology were observed, and its Baker,and scores were determined and the contents of beta-endorphine in different tissues(plasma, skin, hypothalamus) were detected with radioimmunoassay. [Results] After treatment the skin Baker,s scores were decreased in the Chinese drug group as compared with those in the model group(P<0.01). Compared as normal group, the β-EP level in plasma of the rat model with psoriasis-like lesion decreased, but its level in skin increased(P<0.05)and decreased in hypothalamus(P<0.01). After Chinese drug, there were no change in β-EP of plasma, but in skin the β-EP level were lower(P<0.01) and higher in hypothalamus(P<0.01). [Conclusion] The rat model with psoriasis-like lesion can be improved by Chinese drug. The mechanism is possibly related with the down-regulation of β-EP in skin and up-regulation of β-EP in hypothalamus. |
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