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| Comparative study on optimization of silybin particles preparation by uniform design and orthogonal design |
| Hits 1445 Download times 1149 Received:June 29, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2015.12.13 |
| Key Words
silybin;premix membrane emulsification coupling solvent evaporation;micro-particle;uniform design;orthogonal design |
| Author Name | Affiliation | E-mail | | YIN Xue-yan | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China | | | XV Liang-liang | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China | | | YI Xin | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China | | | WU Chen-yue | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China | | | CAI Cheng-ke | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China | cck98@126.com |
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| Abstract
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| [Objective] To prepare silybin micro-particles by premix membrane emulsification coupling solvent evaporation, investigate its preparation procedure, optimize the preparation conditions by the uniform design and orthogonal design, respectively, and compare the two experiment design methods in terms of their feasibility. [Methods] With the average diameter of particle D (0.5) and span as criteria, the uniform design and orthogonal design were used, respectively, to examine the influence of such factors, as the aqueous phase concentration, volume ratio of oil phase to water, pressure through membrane and curing time, on the preparation procedure.[Results] It was found that the optimized preparation procedure was the aqueous phase concentration 3 %, volume ratio of oil phase to water 1:2, pressure through membrane 0.6 MPa and the curing time for 60 min. [Conclusion] The preparation procedure is simple, fast, stable and reliable. The average diameter of particle of the silybin micro-particles is uniform. The uniform design shows a higher feasibility in the present screening test on the preparation procedure of the silybin micro-particles. |
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