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| Experimental study of Xieli Tangshen granules on the high viscosity and high fat microcirculation disturbance in rats with 2 type diabetic nephropathy |
| Hits 1630 Download times 1274 Received:August 14, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2016.01.07 |
| Key Words
Xieli Tangshen granule;diabetic nephropathy;insulin resistance;high viscosity;hyperlipemia;microcirculation disturbance |
| Author Name | Affiliation | | CHAI Xia | Department of Department Traditional Chinere Medicine, The First Hospital of Tianjin, Tianjin 300232, China | | SU Wen-di | Department of Endocrinology, The First Hospital of Tianjin, Tianjin 300232, China | | QIN Li | Liver Disease Research Institution, The First Hospital of Tianjin, Tianjin 300232, China | | ZHAO Peng | Department of Department Traditional Chinere Medicine, The First Hospital of Tianjin, Tianjin 300232, China | | ZHANG Bo-lin | Department of Department Traditional Chinere Medicine, The First Hospital of Tianjin, Tianjin 300232, China |
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| Abstract
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| [Objective] Taking Bushen Xiezhuo as the theoretical basis, using Bushen Xiezhuo Huayu method preparation Xieli Tangshen granule, and to observe the effects of it on high fat, high viscosity and microcirculation in insulin resistance with diabetic nephropathy rats. [Methods] The left kidney of rat was excised, and the rats were fed with high glucose and high fat diet for six weeks. Then, randomly divided into six groups: sham operation group, model group, three different dose groups, and positive control group. Next, detect rats blood glucose, glycosylated hemoglobin (HbA1c), blood and urine, urinary protein, creatinine clearance rate of indicators and observe effect of Xieli Tangshen granules on the carotid artery thrombus formationof rats. [Results] Compared with sham operation group, blood glucose, HbA1c, serum lipid, blood viscosity and urine protein increased in the model group, and insulin sensitivity index(ISI) and creatinine clearance rate decreased, which indicated that insulin resistance diabetic nephropathy model was established, and was accompanied by high cholesterol. Compared with the model group, Xieli Tangshen granules 8, 16 g crude drug dosage group, the levels of blood glucose, HbA1c, TG, whole blood viscosity decreased obviously, urinary protein decreased, creatinine clearance rate increased and extension the carotid artery thrombus formation time. [Conclusion] Xieli Tangshen granules can lower blood glucose and improve ISI and protect renal function and can decrease viscosity, blood fat and extend the carotid artery thrombus formation time on rats with insulin resistance diabetic nephropathy, and the results suggest that the drug has cardiovascular protective effect. |
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