|
| Influence on the balance of Th1/Th2 lymphocyte in the ulcer healing in type 2 diabetic rats treated by the Shengji Xiangpi mastic |
| Hits 1508 Download times 1909 Received:September 26, 2015 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2016.01.08 |
| Key Words
Shengji Xiangpi mastic;diabetic ulcer;immune-inflammation reaction;IL-2;IL-4;IL-10;IFN-γ |
| Author Name | Affiliation | E-mail | | LI Qiao-fen | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | CHANG Bai | Metabolic Diseases Hospital, Tianjin Medical University, Tianjin 300070, China | | | LI Chun-shen | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | lichunshen@126.com |
|
| Abstract
|
| [Objective] To investigate the influence on the balance of Th1/Th2 lymphocyte in the ulcer healing in diabetic rats treated by the Shengji Xiangpi mastic(SM). [Methods] Wistar rats were randomly divided into four groups, one group as the normal control group, the remaining three groups rats injected STZ into vena caudalis as the diabetic model. All the four group rats were punched in back, establishing the diabetic ulcer model. The three group rats of diabetic ulcers were randomly divided into diabetic control group, vaseline group and SM group by the blood glucose and body weight. The changes of IL-2、IL-4、IL-10 and IFN-γ in the wound tissue were observed. [Results] Compare with the rats in normal control group,the contents of IL-2 and IFN-γ were higher and the contents of IL-4 and IL-10 were lower at each selected time point in the rats of the diabetic control group during the experiment, and the difference was significant respectively. Compare with the rats in diabetic control group, the contens of IL-2 and IFN-γ were lower on the 3th, 7th, 14th, 21th, 30th day, while the contents of IL-4 and IL-10 on the 3th, 7th, 14th and 21th day were higher in the rats of SM group, and the difference was significant respectively. [Conclusion] The role of Shengji Xiangpi mastic promoting the ulcer healing in diabetic rats, was closely related to regulate the balance of Th1/Th2 lymphocyte. |
|
|
|
|
|
|
|
