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| Optimization of aqueous extraction-alcohol precipitation technology for Qifang Bimin granules with multi-index orthogonally designed experiments |
| Hits 1609 Download times 1410 Received:October 05, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2016.01.10 |
| Key Words
astragaloside IV;paeoniflorin;water extraction and alcohol precipitation;multi-index |
| Author Name | Affiliation | E-mail | | XUE Dan | College of Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | NI Jian | College of Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | ZHANG Peng | College of Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | YANG Chun-jing | College of Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | ZHAO Yang | College of Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | XIA Zhen-wen | College of Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | | | YIN Xing-bin | College of Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China | yxbtcm@163.com | | LI You-lin | China-Japan Friendship Hospital and Key Laboratory of the State Pharmaceutical Administration, Beijing 100029, China | gjzdyjs2009@163.com |
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| Abstract
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| [Objective] To investigate the technology of optimal water extraction and alcohol precipitation for Qifang Bimin granules with Multi-index. [Methods] The study employed the extraction rate of astragaloside IV and paeoniflorin as evaluation indexes to investigate extraction conditions. We also investigate alcohol precipitation condition in the metastatic rate of astragaloside IV and paeoniflorin as detective index. [Results] The optimal water extraction and alcohol precipitation was extracted 3 times, with 12 folds the amount of water, 1.5 h for each time. The extracts were concentrated to the relative density of 1.15~1.20 (60℃) with the concentration of alcohol precipitation 60%. [Conclusion] Optimized water extraction and alcohol precipitation technology was reasonable and feasible and it could provide a reference for industrial production of Qifang Bimin granules. |
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