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| Determination of sodium and potassium in Danhong injection by atomic absorption spectrometry |
| Hits 1495 Download times 1634 Received:November 24, 2015 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2016.01.11 |
| Key Words
Danhong injection;sodium ion;potassium ion;atomic absorption spectrometry |
| Author Name | Affiliation | E-mail | | WANG Yan | Tianjin State Key Laboratory of Modern Chinese Medicine, Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | | | JIAO Yu-jiao | Tianjin State Key Laboratory of Modern Chinese Medicine, Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | | | ZHU Yan | Tianjin State Key Laboratory of Modern Chinese Medicine, Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | | | WANG Yue-fei | Tianjin State Key Laboratory of Modern Chinese Medicine, Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | | | YANG Jing | Tianjin State Key Laboratory of Modern Chinese Medicine, Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | yangjingfei_2006@163.com |
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| Abstract
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| [Objective] To establish and validate the determination method of the content of sodium ion and potassium ion in Danhong injection by atomic absorption spectrometry (AAS). [Methods] Microwave digestion system was applied to deteriorate samples, and the content of sodium ion and potassium ion was determined by AAS. [Results] The calibration curve of sodium was liner (r=0.999 8) in the range from 0.1 to 0.6 mg/L. The average recovery was 101.1% with RSD 1.8%. The limit of detection was 5.3 μg/L. The calibration curve of potassium was liner (r=0.999 8) in the range from 0.1 to 0.8 mg/L. The average recovery was 99.8% with RSD 2.3%. The limit of detection was 7.7 μg/L. The determination results of 10 batches Danhong injection sample showed that the content of sodium ion was 562.3 to 734.7 mg/L and potassium ion was 206.9 to 314.4 mg/L. [Conclusion] The method is simple and accurate and can be used for determination of the contents of sodium ion and potassium ion in Danhong injection. The accurate quantitative determination method can be promoted to quality control of Danhong injection. |
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