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| Study on the effects of beta cyclodextrin on improving the permeability of salvianolic acid B passing through intestinal mucosa |
| Hits 1589 Download times 1547 Received:October 07, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2016.01.12 |
| Key Words
salvianolic acid B;ussing chamber;intestinal absorption;penetration enhancer |
| Author Name | Affiliation | E-mail | | LIU-Xiao lei | Institute of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Li | Institute of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU-Zhi dong | Institute of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | lonerliuzd@163.com | | LIU Yang | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HU-Li min | Institute of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG-Wei | First People's Hospital in Wu'an, Wu'an 056300, China | |
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| Abstract
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| [Objective] β-cyclodextrin was acted as enhancers to improve the permeability ability of salvianolic acid B passing through the intestinal mucosa. The study also discussed that the penetration enhancing effect of different concentrations of β-cyclodextrin on intestinal mucosal permeability of salvianolic acid B. [Methods] By Ussing chamber technology, duodenum, jejunum, ileum and colon of rats were selected for studying the permeability of salvianolic acid B solution and the addition of β-cyclodextrin in salvianolic acid B solution. [Results] The results showed that: β-cyclodextrin could improve the permeability of salvianolic acid B in duodenum, jejunum and ileum significantly. In 180 min, the resistance of intestine in β-cyclodextrin group was reduced to 65% of the initial resistance value. The promoting effect of 0.13% mass concentration of β-cyclodextrin was better than that of 0.65% and 1.3% mass concentration of β-cyclodextrin. [Conclusion] β-cyclodextrin could improve the permeability of salvianolic acid B passing through the intestinal mucosa, which might be associated with the effect of β-cyclodextrin on opening of the intercellular tight junction proteins. When the concentration of β-cyclodextrin increased from 0.13% to 1.3%, the apparent permeability coefficient of salvianolic acid B decreased along with the increasing of β-cyclodextrin concentration. The mechanism would have to be further studied. |
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