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| Influence of Tetrahydropiperine on transdermal permeation of Glabridin in ointment |
| Hits 2363 Download times 2004 Received:September 16, 2015 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2016.03.13 |
| Key Words
Glabridin;penetration enhancers;transdermal;Tetrahydropiperine |
| Author Name | Affiliation | E-mail | | WANG Yan | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YE Liu-qing | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Yuan-yuan | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HAN Wan-ying | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Li-feng | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | SONg Chun-jing | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Yan-jun | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | zyjsunye@163.com |
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| Abstract
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| [Objective] To investigate the effect of Tetrahydropiperine on transdermal of Glabridin in ointment. [Methods] Franz vertical diffusion cell was adopted to investigate transdermal performance of glabridin and observe the effect of Tetrahydropiperine(THP), azone, borneol on transdermal permeation of Glabridin. [Results] Effect of enhancers on Glabridin was ranked as follows: 0.04%THP > 0.03%THP > 0.02%THP > 5% azone > 3%azone > 2%borneol. When the content of THP was 0.04%, the cumulative permeation of Glabridin was the highest, up to 26.51 μg/cm2. The penetration rate amount with 0.04%THP was 5.03 times than which no permeation enhancer. [Conclusion] These different permeation enhancer have the effect of Glabridin, Glabridin can be permeated quickly and efficiently. |
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