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| Clinical study on treatment of senile gastric cancer chemotherapy related fatigue with Guipi decoction |
| Hits 1734 Download times 1833 Received:February 11, 2016 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2016.04.04 |
| Key Words
Guipi decoction;elderly gastric cancer;cancer-related fatigue;chemotherapy |
| Author Name | Affiliation | E-mail | | WANG Cong | Department of Integrated Chinese and Western Medicine, Tumour Hospital Affiliated to Tianjin Medical University, Nation Tumour Clinical Medicine Research Center, Key Laboratory of Tumour Prevention of Tianjin, Tianjin 300060, China | | | YAN Zhu-chen | Department of Integrated Chinese and Western Medicine, Tumour Hospital Affiliated to Tianjin Medical University, Nation Tumour Clinical Medicine Research Center, Key Laboratory of Tumour Prevention of Tianjin, Tianjin 300060, China | | | WANG Bin | Department of Integrated Chinese and Western Medicine, Tumour Hospital Affiliated to Tianjin Medical University, Nation Tumour Clinical Medicine Research Center, Key Laboratory of Tumour Prevention of Tianjin, Tianjin 300060, China | | | SUN Hai-yan | Department of Integrated Chinese and Western Medicine, Tumour Hospital Affiliated to Tianjin Medical University, Nation Tumour Clinical Medicine Research Center, Key Laboratory of Tumour Prevention of Tianjin, Tianjin 300060, China | | | JIANG Zhan-sheng | Department of Integrated Chinese and Western Medicine, Tumour Hospital Affiliated to Tianjin Medical University, Nation Tumour Clinical Medicine Research Center, Key Laboratory of Tumour Prevention of Tianjin, Tianjin 300060, China | | | PAN Zhan-yu | Department of Integrated Chinese and Western Medicine, Tumour Hospital Affiliated to Tianjin Medical University, Nation Tumour Clinical Medicine Research Center, Key Laboratory of Tumour Prevention of Tianjin, Tianjin 300060, China | wangcongalex@126.com |
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| Abstract
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| [Objective] To observe the clinical effect of Guipi decoction in treatment of senile gastric cancer with chemotherapy related fa-tigue. [Methods] The 84 cases of patients were randomly divided into the treatment group with 42 cases(S-1 combined with Guipi decoc-tion), 42 patients in the control group (chemotherapy with S-1 plus best supportive treatment), observe fatigue of two groups before and af-ter treatment, chemotherapy related side effects, weight and elderly depression degree. [Results] After chemotherapy, occurrence rate of fatigue was 2.3%in treatment group (1 cases), significantly lower than those in control group (7 cases). In weight after chemotherapy, the control group was significantly lower than that in the treatment group (4.06 kg). The difference was statistically significant (P=0.024). The incidence of severe depression was 14%(6 case), and the difference was statistically significant (P=0.044) with 2% (1 cases) in the treat-ment group. After chemotherapy, no adverse reaction of 3/4 grade was found in the treatment group, and the adverse reaction of gastroin-testinal tract in grade 1/2 was significantly less than that of the control group (P=0.001). There was no side effect of 3/4 in the treatment group, and the side effect of 1/2 in the treatment group was less than that in control group (hypoleucocytosis 19%, anemia 12%, thrombo-cytopenia 5%). [Conclusion] Guipi decoction by significantly alleviate the elderly S-1 single agent chemotherapy in patients with blood and gastrointestinal side effects, to improve depression, elderly patients physical enhancement to prevent patients with chemotherapy re-lated fatigue and improve of fatigue effect is obvious. |
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