|
| Effect of decomposed recipes of Tongjiang Hewei decoction on guinea pigs with gastroesophageal reflux induced cough |
| Hits 1618 Download times 1755 Received:January 07, 2016 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2016.04.10 |
| Key Words
gastroesophageal reflux induced cough;airway neurogenic inflammation;pulmonary capillary permeability;Tongjianghewei decoction |
| Author Name | Affiliation | E-mail | | LIU Chun-fang | Digestive Department, Yueyang Hospital of Integrated Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | CAO Hui-jie | Traditional Chinese Medicine Internal Department, Putuo District Central Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200002, China | | | CHENG Yan-mei | Digestive Department, Yueyang Hospital of Integrated Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | WANG Hong-wei | Digestive Department, Yueyang Hospital of Integrated Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | ZHANG Xiu-lian | Digestive Department, Yueyang Hospital of Integrated Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | ZHU Sheng-liang | Digestive Department, Yueyang Hospital of Integrated Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | zhushengliang99@163.com |
|
| Abstract
|
| [Objective] To observe the effect of the Tongjiang Hewei decoction on airway inflammation and pulmonary tissue permeability in guinea pig model of gastroesophageal reflux induced cough. [Methods] Sixty healthy male guinea pigs were randomly divided into 6 groups:Tongjiang Hewei group, Shugan Xiere group, Hewei Jiangni group, control group, model group and normal group. GERC models were induced repeatedly by hydrochloric acid instillation, except normal group, given the corresponding intervention measures to each group. After two weeks, execute all animals and observe the histological changes of the esophagus and trachea; evans Blue-invasive method for the determination of pulmonary capillary permeability in guinea pigs. [Results] 1)The inflammation of esophagus and trachea in model group was much more obviously than the normal group; the interaction between Shugan Xiere group and Hewei Jiangni group was significant in improving the guinea pig esophagus and trachea tissue inflammation. Comparing Tongjiang Hewei decoction with omeprazole, there was a significant difference in improving the guinea pig esophagus and trachea pathologic scores (P<0.05). 2) Permeability of the model lung tissue than normal group was significantly increased respectively(P<0.05); the interaction between Shugan Xiere group and Hewei Jiangni group was significant in improving the permeability(P<0.05); Tongjiang Hewei decoction and omeprazole had a significant difference in this area(P<0.05). [Conclusion] Tongjiang Hewei decoction can effectively improve the guinea pig esophagus and trachea inflammation, reduce the permeability of the lung tissue, thereby reduce the inflammatory exudate and cure cough. |
|
|
|
|
|
|
|
