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| Effects of Xuanfu Daizhe decoction on Na+-K+-ATP and Ca2+-Mg2+-ATP enzymes activity of plasma in reflux esophagitis rats |
| Hits 2316 Download times 1644 Received:December 25, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2016.04.11 |
| Key Words
reflux esophagitis;Xuanfu Daizhe decoction;ascending and descending of Qi;Na+-K+-ATPase and Ca2+-Mg2+-ATPase |
| Author Name | Affiliation | E-mail | | MIAO Jia-meng | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YANG You-xin | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | youxin_yang@hotmail.com | | MA Yan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | XU Yun-jiao | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | DENG Yan-rong | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | QI Jing-tian | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YUAN Hong-xia | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] Expolration on the esophageal mucosa cell energy metabolism dysfunction and mucosal damage and function mechanism of Inula Daizhe decoction in treating reflux esophagitis (RE). [Methods] The 120 Wistar rats were randomly divided into 10 groups, with 12 rats in each group and normal control group, model control group, Inula Daizhe decoction group Quanfang group, Kujiang group, Gansheng group, Shengjiang Xiangyin group, Quanfang subtraction Kujiang group, Quanfang subtraction Gansheng group, Quanfang subtraction Shengjiang Xiangyin group and Western medicine group; in addition to the normal control group (normal group), the other 9 groups molding by "4.2 mm pylorus clamp+gastric bottom two-thirds ligation", after treatment of 14 days, the rats were sacrificed, and the activity of Na+-K+-ATP and Ca2+-Mg2+-ATP in plasma was detected. [Results] After the experiment ATP enzyme activity in the model group rats lower than normal control group; enzymes activity in Quanfang group and Western medicine group was best, compared with normal group, and the difference was not obvious, compared with model group the difference was significant (P<0.05); compared with Kujiang group and Quanfang subtraction Gansheng group with model group, the difference was not statistically significant (P>0.05). Compared with Quanfang group and Western medicine group, it was statistical significance (P<0.05). Compared the normal group with the other groups, the differences were statistically significant (P<0.05); compared Western medicine group with Quanfang group, the difference was no statistically significant. [Conclusion] Xuanfu Daizhe decoction Quanfang group can improve plasma Na+-K+-ATPase and Ca2+-Mg2+-ATPase activity in the model rat, improve the model of rat esophageal mucosa tissue morphologic changes and the effect is better than that of the demolition party group. |
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