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| Simultaneous determination of seven constituents in Wenlikang granules by quantitative analysis of multi-components by single marker |
| Hits 1996 Download times 1600 Received:November 30, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2016.04.14 |
| Key Words
Weilikang granules;quantitative analysi of multi-components by single marker;UPLC;quality control |
| Author Name | Affiliation | E-mail | | CHAI Shi-wei | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | TU Ya-ru | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Xing-rui | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LIU Er-wei | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | CHANG Yan-xu | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | HE Jun | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Tianjin State Key Laboratory of Modern Chinese Medicine-Province and Ministry Co-established State Key Laboratory Cultivation Base, Tianjin 300193, China | hejun673@163.com |
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| Abstract
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| [Objective] To establish a method for simultaneous determination of seven bioactive components in Weilikang Granules by quantitative analysis of multi-components by single marker (QAMS). [Methods] Peoniflorin was select as an index, relative correction factors of Rutin, Naringin, Rosmarinic acid, Salvianolic acid B, Emodin-8-O-β-D-glucopyranoside and Glycyrrhizic acid were established by UPLC and calculated to achieve QAMS. The accuracy of the new method was evaluated by comparing the results between QAMS and the external standard method. [Results] The analysis method was established and there is no significant difference between the calculated contents and the contents which were determined by external reference method in 10 batches of samples. [Conclusion] The QAMS method is reliable, accurate to control the quality of seven bioactive components of Weilikang granules. |
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