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| A simple and efficient method for preparation of bakuchiol |
| Hits 2544 Download times 1751 Received:March 26, 2016 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2016.04.15 |
| Key Words
Fructus Psoraleae;Bakuchiol;cold-maceration |
| Author Name | Affiliation | E-mail | | ZHANG Bo-yong | Institute of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Province and Minstry Co-established State Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | | | CHAI Xin | Institute of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Province and Minstry Co-established State Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | | | WANG Yue-fei | Institute of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Province and Minstry Co-established State Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | wangyuefei_2006@hotmail.com | | JIANG Zhen-zuo | Institute of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Province and Minstry Co-established State Key Laboratory, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
Research and Development Center of Traditional Chinese Medicine, Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin 300457, China | |
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| Abstract
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| [Objective] To establish a simple and efficient method for the preparation of bakuchiol. [Methods] The powder of Fructus Psoraleae was extracted with petroleum ether by maceration to get the crude extract of bakuchiol. The crude extract was subjected to silica gel column chromatography and eluted with petroleum ether to achieve the crude product of bakuchiol, then further treated with petroleum ether and ethyl acetate (12:1) to achieve bakuchiol. [Results] Bakuchiol, characteristed by 1H NMR, 13C NMR was obtained with the purity above 98%, which was determined by UPLC-DAD at 246 nm. The yield of bakuchiol was 1.0%. [Conclusion] The method is simple, rapid and efficient, can prepare a large number of bakuchiol. |
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