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| Anti-inflammatory effect and mechanism study of Cordycepin |
| Hits 1541 Download times 1502 Received:February 23, 2016 |
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| DOI
10.11656/j.issn.1672-1519.2016.05.12 |
| Key Words
Cordycepin;anti-inflammation;NO;PGE2;iNOS;COX-2 |
| Author Name | Affiliation | E-mail | | LI Hui | Shenzhen Nanshan District Hospital, Shengzhen 518067, China | | | SUN Jia-yu | Shenzhen Futian District Traditional Chinese Medicine Hospital, Shengzhen 518033, China | | | LIAO Kang-han | Shenzhen Nanshan District Hospital, Shengzhen 518067, China | | | WANG Zhe | Central South University Xiangya School of Medicine, Changsha 410013, China | | | SHAN Ai-yun | Shenzhen Futian District Traditional Chinese Medicine Hospital, Shengzhen 518033, China | 1348903@qq.com |
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| Abstract
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| [Objective] To study the anti-inflammatory effect of Cordycepin. [Methods] By Xylene induce ear swelling test in mice, the inhibition of Cordycepin (50, 100, 200 mg/kg)was evaluated for ear swelling. At the cellular level, the effect of Cordycepin(12.5, 25, 50 μmol/L)was evaluated for iNOS and COX-2 expression, NO and PGE2 production. [Results] Cordycepin(200 mg/kg)inhibited ear swelling of mice (P<0.05), NO and PGE2 production in mouse ear piece(P<0.05). At the cellular model, Cordycepin (25, 50 μmol/L)inhibited iNOS and COX-2 expression(P<0.05),NO and PGE2 production(P<0.05). [Conclusion] Cordycepin have anti-inflammatory effect. |
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