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| Biological effects of different concentrations of Puerarin solution on human skin fibroblast |
| Hits 1509 Download times 1421 Received:November 28, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2016.05.14 |
| Key Words
Puerarin;human skin fibroblasts;drug concentration;biological effect |
| Author Name | Affiliation | E-mail | | YUE Dong-mei | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | YAN Bing | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MA Yi-wen | Tanggu Maternity Hospital of Tianjin Binhai New Area, Tianjin 300451, China | | | WANG Yi-min | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | MENG Qing-nan | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | mqn1234@163.com |
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| Abstract
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| [Objective] To observe biological effects of different concentrations of puerarin solution on proliferation of human skin fibroblasts (HDF). [Methods] Cultivated human skin fibroblasts in vitro, observed biological effects of puerarin solutions of 100, 200, 300, 400, 500 μg/mL five different drug concentrations on HDF. [Results] Compared with control group, drug concentration of 100, 200, 300, 400 μg/mL of puerarin solution had no influence on biological effects of HDF. Drug concentration of 500 μg/mL of puerarin solution inhibited proliferation of HDF, had a certain damage on cell membranes of HDF. [Conclusion] Puerarin solution of 500 μg/mL can inhibit proliferation of HDF and have damage on cell membranes of HDF cultured in vitro, this drug concentration can be used as the dose of HDF intervention, will play a role in treatment of scar tissue. |
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