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| Study on the anti-tumor effect mechanism of Gancao polysaccharide on production of IL-7 |
| Hits 2035 Download times 1354 Received:December 24, 2015 |
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| DOI
10.11656/j.issn.1672-1519.2016.06.14 |
| Key Words
Gancao polysaccharide;small intestinal mucosal epithelial cell;anti-tumor;IL-7 |
| Author Name | Affiliation | E-mail | | WANG Li | The Second People's Hospital of Tianjin, Tianjin 300192, China
Tianjin Medical Research Institute of Liver Disease, Tianjin 300192, China | | | ZHAO Ying | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | CUI Huan-tian | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | LI Wei | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | SONG Xin-bo | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | | | BIAN Yu-hong | Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China | bianyuhong_2012@163.com |
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| Abstract
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| [Objective] To elucidate the mechanism of Gancao polysaccharide (GP) on anti-tumor. [Methods] CT-26 cells were used to set up the tumor-bearing model in mice. The mice were respectively divided into following groups: normal group, model group, GP group (GP i.g, 500 mg/kg), letinan group (letinan i.g, 195 mg/kg) and IL-7 antibody group (GP i.g, 500 mg/kg, IL-7antibody i.p,.0.4 mg/kg on day 0, 5 and 10). After administration of GP for 14 days, the tumor, spleen and thymus were weighted to measure the tumor inhibition rat, spleen index and thymus index. [Results] After the administration of GP for 14 days, the tumor inhibition rate in GP group was 21.56%.The IL-7 gene expression in GP group was upregulated and the serum level of IL-7 was increased in GP group. The tumor inhibition rate and thymus index were decreased in IL-7 antibody group followed by the significant lower IL-7 level in serum in spite of the IL-7 gene expressed in intestine. [Conclusion] This study demonstrated that GP exert significant anti-tumor effect and the mechanism behind the anti-tumor effect may relate to the IL-7 production of intestinal epithelial cells. |
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