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| Progress in biotransformation and pharmacological activities of gentiopicroside and gentianine |
| Hits 7394 Download times 2741 Received:March 01, 2016 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2016.07.01 |
| Key Words
gentiopicroside;gentianine;biotransformation;pharmacological activity |
| Author Name | Affiliation | E-mail | | KUANG Hai-xue | Key Laboratory of Heilongjiang University of Traditional Chinese Medicine of Ministry of Education Beiyao Foundation and Application, Key Laboratory of Traditional Chinese Medicine in Heilongjiang Province Natural Drug Efficacy Study on the Material Foundation, Harbin 150040, China | | | WU Gao-song | Key Laboratory of Heilongjiang University of Traditional Chinese Medicine of Ministry of Education Beiyao Foundation and Application, Key Laboratory of Traditional Chinese Medicine in Heilongjiang Province Natural Drug Efficacy Study on the Material Foundation, Harbin 150040, China | | | LIU Hua | Key Laboratory of Heilongjiang University of Traditional Chinese Medicine of Ministry of Education Beiyao Foundation and Application, Key Laboratory of Traditional Chinese Medicine in Heilongjiang Province Natural Drug Efficacy Study on the Material Foundation, Harbin 150040, China | | | WU Qiong | Key Laboratory of Heilongjiang University of Traditional Chinese Medicine of Ministry of Education Beiyao Foundation and Application, Key Laboratory of Traditional Chinese Medicine in Heilongjiang Province Natural Drug Efficacy Study on the Material Foundation, Harbin 150040, China | | | WANG Qiu-hong | Key Laboratory of Heilongjiang University of Traditional Chinese Medicine of Ministry of Education Beiyao Foundation and Application, Key Laboratory of Traditional Chinese Medicine in Heilongjiang Province Natural Drug Efficacy Study on the Material Foundation, Harbin 150040, China | | | WANG Zhi-bin | Key Laboratory of Heilongjiang University of Traditional Chinese Medicine of Ministry of Education Beiyao Foundation and Application, Key Laboratory of Traditional Chinese Medicine in Heilongjiang Province Natural Drug Efficacy Study on the Material Foundation, Harbin 150040, China | wzbmailbox@126.com |
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| Abstract
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| Gentiopicroside is one of important iridoid compounds, and the main active constituents of plants of the genus Gentiana, and can promote the gastric emptying and intestinal peristalsis and protecting liver, analgesic, anti-inflammatory and action. Gentianine has anti-inflammatory, antipyretic, sedative hypnotic, and anticonvulsant effect. Researchers have found that gentiopicroside and other iridoid compounds can be converted to gentianine and novel active components under the action of plant endophytic fungi and human intestinal bacteria. The gentiopicroside and gentianine in recent years in the pharmacological activity, biotransformation and metabolism is summarized in the article, to provide a theoretical basis for the further development and utilization of iridoid compounds and their metabolites. |
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